Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support stopping smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. Was diagnosed with Chronic Fatigue. Anxiety was more of an issue than depression, but was put on Wellbutrin 150 XL because dr. had had success with it and said depression and anxiety are different sides of the same coin when I questioned being put on an antidepressant when I was anxious. Describes the medication bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL) an antidepressant drug used to manage depression, and also to help with smoking cessation. Article includes descriptions, uses, drug interactions, and side effects. According to the FDA Budeprion XL 300 mg (manufactured by Impax Laboratories) is NOT therapeutically equivalent to Wellbutrin XL 300 mg 4. Bupropion was first synthesized by Burroughs Research in 1966, and patented by Burroughs-Wellcome (later Glaxo-Wellcome) in 1974. DESCRIPTION. WELLBUTRIN XL® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. It wasnt until two days ago that I called my doctor and she said to stop cutting the XL in half immediately. The next day I took a Wellbutrin 150 MG SR pill I had left over, and I had a similar reaction. Hi Dia I’m 71 and on 150 xl Wellbutrin …. I have Hashimoto Thyroid and isn’t under control so I was thinking of asking my doctor if I should up my Wellbutrin. I have been taking 150 mg of Wellbutrin for a month. My Dr wants me to go to 300 mg. Will I feel a lot better taking the 300mg? Has anybody gone from 150 to 300 mg of Wellbutrin. Initially, 150 mg PO once daily in the morning. After no less than 4 days, titrate to the usual target dose of 300 mg PO once daily in the morning based upon patient response and tolerance. Hi, first, it is not uncommon for your symptoms to respond to a lower level of medication that is necessitated to make them less vegetative and lessen the paralyzing impact on an individuals' life and ability to function successfully daily.